一、Bladder Cancer膀胱癌
1. Chiu KY, Wu CC, Chia CH, Hsu SL, Tzeng YM. Inhibition of growth, migration and invasion of human bladder cancer cells by antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, and its molecular mechanisms. Cancer Lett. 2016 Apr 10;373(2):174-84. doi: 10.1016/j.canlet.2015.11.046. Epub 2015 Dec 8. PMID: 26679052.
从牛樟芝中分离出的Antrocin抑制膀胱癌细胞的生长，迁移和侵袭及其分子机制
2. Peng CC, Chen KC, Peng RY, Chyau CC, Su CH, Hsieh-Li HM. Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells. J Ethnopharmacol. 2007 Jan 3;109(1):93-103. doi: 10.1016/j.jep.2006.07.009. Epub 2006 Jul 11. PMID: 16930895.
牛樟芝提取物在浅表TCC中诱导复制性衰老，并抑制浸润性膀胱癌细胞的绝对迁移能力
3. Peng CC, Chen KC, Peng RY, Su CH, Hsieh-Li HM. Human urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata extracts. Cancer Lett. 2006 Nov 8;243(1):109-19. doi: 10.1016/j.canlet.2005.11.021. Epub 2006 Feb 7. PMID: 16455193.
膀胱癌T24细胞对樟芝牛樟芝提取物敏感
二、Breast Cancer乳腺癌
1. Chen YC, Liu YC, El-Shazly M, Wu TY, Chang JG, Wu YC. Antrodia cinnamomea, a Treasured Medicinal Mushroom, Induces Growth Arrest in Breast Cancer Cells, T47D Cells: New Mechanisms Emerge. Int J Mol Sci. 2019 Feb 15;20(4):833. doi: 10.3390/ijms20040833. PMID: 30769922; PMCID: PMC6412332.
珍贵的药用菌牛樟芝可诱发乳腺癌细胞T47D细胞的生长停滞：新机制的出现
2. Chen JH, T H Wu A, T W Tzeng D, Huang CC, Tzeng YM, Chao TY. Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling. Phytomedicine. 2019 Jan;52:70-78. doi: 10.1016/j.phymed.2018.09.213. Epub 2018 Sep 27. PMID: 30599914.
Antrocin是一种来自牛樟芝的生物活性成分，它通过下调β-catenin/Notch1/Akt信号传导抑制乳腺癌的发生和干性
3. Hseu YC, Chang GR, Pan JY, Rajendran P, Mathew DC, Li ML, Liao JW, Chen WT, Yang HL. Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers. J Cell Physiol. 2019 Apr;234(4):4125-4139. doi: 10.1002/jcp.27222. Epub 2018 Aug 26. PMID: 30146779.
牛樟芝通过靶向三阴性乳腺癌中的多种途径来抑制上皮向间充质转化
4. Hseu YC, Chen SC, Chen HC, Liao JW, Yang HL. Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo. Food Chem Toxicol. 2008 Aug;46(8):2680-8. doi: 10.1016/j.fct.2008.04.036. Epub 2008 May 4. PMID: 18550246.
牛樟芝在体外和体内均能抑制人乳腺癌细胞的增殖
5. Hseu YC, Chen SC, Tsai PC, Chen CS, Lu FJ, Chang NW, Yang HL. Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata. Food Chem Toxicol. 2007 Jul;45(7):1107-15. doi: 10.1016/j.fct.2006.12.012. Epub 2006 Dec 27. PMID: 17391824.
牛樟芝抑制环氧合酶-2并诱导雌激素-无应答乳腺癌细胞凋亡
6. Lee CC, Yang HL, Way TD, Kumar KJ, Juan YC, Cho HJ, Lin KY, Hsu LS, Chen SC, Hseu YC. Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2012;2012:702857. doi: 10.1155/2012/702857. Epub 2012 Jun 3. PMID: 22701509; PMCID: PMC3371823.
牛樟芝在HER-2/neu过表达的乳腺癌细胞中通过诱导ROS，消耗HER-2/neu以及破坏PI3K/Akt信号通路来抑制细胞生长和诱导凋亡
7. Lin WL, Lee YJ, Wang SM, Huang PY, Tseng TH. Inhibition of cell survival, cell cycle progression, tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide. B. Eur J Pharmacol. 2012 Apr 5;680(1-3):8-15. doi: 10.1016/j.ejphar.2012.01.032. Epub 2012 Feb 10. PMID: 22329896.
牛樟芝camphorataimide B抑制MDA-MB-231乳腺癌细胞存活，细胞周期进程，肿瘤生长和环氧合酶-2活性
8. Lin YS, Lin YY, Yang YH, Lin CL, Kuan FC, Lu CN, Chang GH, Tsai MS, Hsu CM, Yeh RA, Yang PR, Lee IY, Shu LH, Cheng YC, Liu HT, Lee KD, Chang DC, Wu CY. Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway. BMC Complement Altern Med. 2018 May 9;18(1):152. doi: 10.1186/s12906-018-2204-y. PMID: 29743060; PMCID: PMC5944021.
牛樟芝提取物通过细胞凋亡和skp2/microRNAs途径抑制他莫昔芬耐药乳腺癌细胞的增殖
9. Peng CY, Fong PC, Yu CC, Tsai WC, Tzeng YM, Chang WW. Methyl Antcinate A suppresses the population of cancer stem-like cells in MCF7 human breast cancer cell line. Molecules. 2013 Feb 26;18(3):2539-48. doi: 10.3390/molecules18032539. PMID: 23442930; PMCID: PMC6270214.
Methyl Antcinate A 抑制MCF7人乳腺癌细胞系中癌干样细胞的聚集
10. Rao YK, Wu AT, Geethangili M, Huang MT, Chao WJ, Wu CH, Deng WP, Yeh CT, Tzeng YM. Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells. Chem Res Toxicol. 2011 Feb 18;24(2):238-45. doi: 10.1021/tx100318m. Epub 2010 Dec 15. PMID: 21158420.
牛樟芝中抗癌蛋白的鉴定是转移性乳腺癌MDA-MB-231细胞中选择性和新型的Akt/mTOR信号小分子抑制剂
11. Yang HL, Chen CS, Chang WH, Lu FJ, Lai YC, Chen CC, Hseu TH, Kuo CT, Hseu YC. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Lett. 2006 Jan 18;231(2):215-27. doi: 10.1016/j.canlet.2005.02.004. PMID: 16399223.
牛樟芝对MCF-7乳腺癌细胞的生长抑制和凋亡诱导
12. Yang H, Kumar K, Hseu Y. Multiple Molecular Targets of Antrodia camphorata: A Suitable Candidate for Breast Cancer Chemoprevention. Targeting New Pathways and Cell Death in Breast Cancer. 2012 Feb;10:157-181. doi: 10.5772/21789.
牛樟芝的多个分子靶标：适合乳腺癌化学预防的候选对象
13. Yang HL, Kuo YH, Tsai CT, Huang YT, Chen SC, Chang HW, Lin E, Lin WH, Hseu YC. Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem Toxicol. 2011 Jan;49(1):290-8. doi: 10.1016/j.fct.2010.10.031. Epub 2010 Nov 4. PMID: 21056076.
牛樟芝通过抑制MAPK信号通路介导的乳腺癌细胞的抗转移活性
三、Colon Cancer结直肠癌
1. Kobori M, Yoshida M, Ohnishi-Kameyama M, Shinmoto H. Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells. Br J Pharmacol. 2007 Jan;150(2):209-19. doi: 10.1038/sj.bjp.0706972. Epub 2006 Dec 11. PMID: 17160010; PMCID: PMC2042906.
药食用菌中的麦角固醇过氧化物抑制RAW264.7巨噬细胞中的炎症反应和HT29结肠腺癌细胞的生长
2. Lien HM, Kuo PT, Huang CL, Kao JY, Lin H, Yang DY, Lai YY. Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells. Evid Based Complement Alternat Med. 2011;2011:450529. doi: 10.1093/ecam/nep230. Epub 2011 May 3. Erratum in: Evid Based Complement Alternat Med. 2012;2012:148127. PMID: 21785624; PMCID: PMC3138483.
牛樟芝的SY-1的5-取代4,7-二甲氧基-1,3-苯并二恶唑SY-1衍生物对人COLO 205结肠癌细胞的抗增殖活性研究
3. Lin TJ, Lai KC, Lee AS, Chang CH, Liu CL, Chung CH. Novel Antrodia cinnamomea Extract Reduced Cancer Stem-Like Phenotype Changes and Resensitized KRAS-Mutant Colorectal Cancer via a MicroRNA-27a Pathway. Cancers (Basel). 2019 Oct 26;11(11):1657. doi: 10.3390/cancers11111657. PMID: 31717759; PMCID: PMC6896121.
新型牛樟芝提取物通过MicroRNA-27a途径减少癌症茎样表型变化并重新敏化KRAS突变型结直肠癌
4. Lin HC, Lin MH, Liao JH, Wu TH, Lee TH, Mi FL, Wu CH, Chen KC, Cheng CH, Lin CW. Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets. J Agric Food Chem. 2017 Jan 11;65(1):51-59. doi: 10.1021/acs.jafc.6b04101. Epub 2016 Dec 20. PMID: 27997180.
Antroquinonol是牛樟芝中的泛醌衍生物，抑制结肠癌干细胞样性质：分子机制和抑制目标的见解
5. Lien HM, Lin HW, Wang YJ, Chen LC, Yang DY, Lai YY, Ho YS. Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human Colorectal Carcinoma Cells by 4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated from the Fruiting Body of Antrodia camphorate. Evid Based Complement Alternat Med. 2011;2011:984027. doi: 10.1093/ecam/nep020. Epub 2011 Jun 8. PMID: 19293251; PMCID: PMC3137876.
从牛樟芝实体子中分离得到的4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated对结肠直肠癌细胞中锚定非依赖性增殖和G0/G1细胞周期调控的抑制作用
6. Tsai DH, Chung CH, Lee KT. Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells. Sci Rep. 2018 Nov 27;8(1):17424. doi: 10.1038/s41598-018-35780-y. PMID: 30479369; PMCID: PMC6258711.
牛樟芝通过CHOP/TRB3/Akt/mTOR途径在大肠癌细胞中诱导自噬细胞死亡
7. Yeh CT, Rao YK, Yao CJ, Yeh CF, Li CH, Chuang SE, Luong JH, Lai GM, Tzeng YM. Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. Cancer Lett. 2009 Nov 18;285(1):73-9. doi: 10.1016/j.canlet.2009.05.002. Epub 2009 May 23. PMID: 19477064.
牛樟芝的细胞毒性三萜及其在HT-29结肠癌细胞中的作用方式
四、Esophageal Cancer食管癌
1. Liu YM, Liu YK, Huang PI, Tsai TH, Chen YJ. Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells. Food Chem Toxicol. 2018 Sep;119:380-386. doi: 10.1016/j.fct.2018.01.028. Epub 2018 Feb 21. PMID: 29475041.
牛樟芝菌丝体发酵液抑制食道腺癌细胞的上皮-间质转化
五、Glioblastomas胶质母细胞瘤
1. Deng JY, Chen SJ, Jow GM, Hsueh CW, Jeng CJ. Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas. Chem Res Toxicol. 2009 Nov;22(11):1817-26. doi: 10.1021/tx9002275. PMID: 19848398.
Dehydroeburicoic Acid在U87MG胶质母细胞瘤中诱导钙和钙蛋白酶依赖性坏死
2. Liu HW, Su YK, Bamodu OA, Hueng DY, Lee WH, Huang CC, Deng L, Hsiao M, Chien MH, Yeh CT, Lin CM. The Disruption of the β-Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetyl antroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo. Cancers (Basel). 2018 Dec 5;10(12):491. doi: 10.3390/cancers10120491. PMID: 30563094; PMCID: PMC6315804.
4-Acetyl antroquinonol B破坏β-Catenin/TCF-1/STAT3信号轴将在体外和体内抑制胶质母细胞瘤细胞的肿瘤发生和癌干细胞样特性
六、Head and Neck Cancer头颈癌
1. Chang CW, Chen YS, Chen CC, Chen CC, Sheu SJ, Lin TW, Lee TC, Lo JF. Lyophilized particles and ethanolic extracts of Antrodia cinnamomea mycelia suppress the tumorigenicity of head and neck cancer cells in vivo. Biomedicine (Taipei). 2014;4(4):26. doi: 10.7603/s40681-014-0026-x. Epub 2014 Nov 22. PMID: 25520939; PMCID: PMC4265012.
牛樟芝菌丝体的冻干颗粒和乙醇提取物在体内抑制头颈癌细胞的致瘤性
七、Kidney Cancer肾癌
1. Chiu KY, Chen TH, Wen CL, Lai JM, Cheng CC, Liu HC, Hsu SL, Tzeng YM. Antcin-H Isolated from Antrodia cinnamomea Inhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP-β/c-Fos-MMP-7 Pathways. Evid Based Complement Alternat Med. 2017;2017:5052870. doi: 10.1155/2017/5052870. Epub 2017 Nov 2. PMID: 29234409; PMCID: PMC5688354.
从牛樟芝分离的Antcin-H部分抑制FAK-ERK-C/EBP-β/c-Fos-MMP-7途径的抑制肾癌细胞的侵袭
八、Leukemia白血病
1. Chen YJ, Chou CJ, Chang TT. Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells. Toxicol In Vitro. 2009 Apr;23(3):418-24. doi: 10.1016/j.tiv.2009.01.011. Epub 2009 Jan 22. PMID: 19344682.
化合物MMH01具有抗白血病和胰腺癌细胞的毒性
2. Du YC, Chang FR, Wu TY, Hsu YM, El-Shazly M, Chen CF, Sung PJ, Lin YY, Lin YH, Wu YC, Lu MC. Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models. Phytomedicine. 2012 Jun 15;19(8-9):788-96. doi: 10.1016/j.phymed.2012.03.014. Epub 2012 Apr 18. PMID: 22516893.
牛樟芝中的抗白血病成分dehydroeburicoic acid在体外和体内模型中诱导DNA损伤和细胞凋亡
3. Lin SY, Sheen LY, Chiang BH, Yang JS, Pan JH, Chang YH, Hsu YM, Chiang JH, Lu CC, Wu CL, Chung JG. Dietary effect of Antrodia Camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice. Nutr Cancer. 2010;62(5):593-600. doi: 10.1080/01635580903532341. PMID: 20574920.
牛樟芝提取物对WEHI-3白血病BALB/c小鼠免疫反应的饮食作用
4. Lu MC, Du YC, Chuu JJ, Hwang SL, Hsieh PC, Hung CS, Chang FR, Wu YC. Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. Arch Toxicol. 2009 Feb;83(2):121-9. doi: 10.1007/s00204-008-0337-3. Epub 2008 Aug 16. PMID: 18709356.
樟芝野生子实体的有效提取物(EEAC)通过组蛋白低乙酰化部分诱导白血病HL 60细胞凋亡，并协同促进曲古抑菌素A的抗癌作用
九、Liver Cancer肝癌
1. Chang CY, Cheng TJ, Chang FR, Wang HY, Kan WC, Li SL, Huang LH, Chen YC, Tsai WC, Huang CH, Cheng CH, Lee GY, Shyue SW, Chen YP, Lin KC, Chuu JJ. Macrophage mediated anti-proliferation effects of Anthodia camphorata non-polysaccharide based extracts on human hepatoma cells. Biosci Biotechnol Biochem. 2011;75(4):624-32. doi: 10.1271/bbb.100559. Epub 2011 Apr 22. PMID: 21512226.
巨噬细胞介导的牛樟芝非多糖提取物对肝癌细胞的抗增殖作用
2. Chang CY, Huang ZN, Yu HH, Chang LH, Li SL, Chen YP, Lee KY, Chuu JJ. The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells. J Ethnopharmacol. 2008 Aug 13;118(3):387-95. doi: 10.1016/j.jep.2008.05.001. Epub 2008 May 7. PMID: 18571350.
牛樟芝提取物与抗肿瘤剂联合对多药耐药肝癌细胞的佐剂作用
3. Chen SY, Lee YR, Hsieh MC, Omar HA, Teng YN, Lin CY, Hung JH. Enhancing the Anticancer Activity of Antrodia cinnamomea in Hepatocellular Carcinoma Cells via Cocultivation With Ginger: The Impact on Cancer Cell Survival Pathways. Front Pharmacol. 2018 Jul 18;9:780. doi: 10.3389/fphar.2018.00780. PMID: 30072899; PMCID: PMC6058215.
通过与姜共培养来增强牛樟芝在肝癌细胞中的抗癌活性：对癌细胞存活途径的影响
4. Chen YS, Pan JH, Chiang BH, Lu FJ, Sheen LY. Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes. J Food Sci. 2008 Sep;73(7):H179-85. doi: 10.1111/j.1750-3841.2008.00884.x. Epub 2008 Aug 18. PMID: 18803715.
不同时间和规模发酵的牛樟芝菌丝体的乙醇提取物对肝癌细胞和正常原代肝细胞具有不同的作用
5. Chiang PC, Lin SC, Pan SL, Kuo CH, Tsai IL, Kuo MT, Wen WC, Chen P, Guh JH. Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. Biochem Pharmacol. 2010 Jan 15;79(2):162-71. doi: 10.1016/j.bcp.2009.08.022. Epub 2009 Aug 31. PMID: 19723512.
Antroquinonol显示出对肝癌细胞的抗癌潜力：AMPK和mTOR通路的关键作用
6. Hsu YL, Kuo PL, Cho CY, Ni WC, Tzeng TF, Ng LT, Kuo YH, Lin CC. Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kappaB pathway. Food Chem Toxicol. 2007 Jul;45(7):1249-57. doi: 10.1016/j.fct.2007.01.005. Epub 2007 Jan 17. PMID: 17316946.
牛樟芝子实体提取物通过抑制核因子kappaB p途径抑制人肝癌细胞株PLC/PRF/5的侵袭潜力
7. Hsieh YC, Rao YK, Whang-Peng J, Huang CY, Shyue SK, Hsu SL, Tzeng YM. Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. J Agric Food Chem. 2011 Oct 26;59(20):10943-54. doi: 10.1021/jf202771d. Epub 2011 Oct 5. PMID: 21916504.
牛樟芝Bantcin B及其酯衍生物诱导肝癌细胞凋亡涉及增强氧化应激并启动内在和外在凋亡途径
8. Hsieh YC, Rao YK, Wu CC, Huang CY, Geethangili M, Hsu SL, Tzeng YM. Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway. Chem Res Toxicol. 2010 Jul 19;23(7):1256-67. doi: 10.1021/tx100116a. PMID: 20557081.
牛樟芝中的Methyl antcinate A通过氧化剂介导的cofilin和Bax触发的线粒体途径诱导肝癌细胞凋亡
9. Kuo PL, Hsu YL, Cho CY, Ng LT, Kuo YH, Lin CC. Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells. Food Chem Toxicol. 2006 Aug;44(8):1316-26. doi: 10.1016/j.fct.2006.02.009. Epub 2006 Feb 28. PMID: 16600460.
牛樟芝子实体提取物的凋亡作用是通过Hep 3B细胞中钙和钙蛋白酶依赖性途径介导
10. Li SL, Huang ZN, Hsieh HH, Yu WC, Tzeng WY, Lee GY, Chen YP, Chang CY, Chuu JJ. The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells. Am J Chin Med. 2009;37(4):771-83. doi: 10.1142/S0192415X09007235. PMID: 19655414.
牛樟芝与中草药共同发酵对肝癌细胞的增强抗肿瘤作用
11. Liu YM, Liu YK, Lan KL, Lee YW, Tsai TH, Chen YJ. Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma. Evid Based Complement Alternat Med. 2013;2013:569737. doi: 10.1155/2013/569737. Epub 2013 Mar 6. PMID: 23533499; PMCID: PMC3606723.
药用真菌牛樟芝抑制肝细胞癌的生长和癌干细胞特性
12. Lin YW, Chiang BH. 4-acetyl antroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J Agric Food Chem. 2011 Aug 24;59(16):8625-31. doi: 10.1021/jf2011326. Epub 2011 Jul 26. PMID: 21739974.
从牛樟芝中分离得到的4-acetylantroquinonol B通过影响p53，p21和p27水平阻止肝癌HepG2细胞的增殖
13. Lin YW, Pan JH, Liu RH, Kuo YH, Sheen LY, Chiang BH. The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. J Sci Food Agric. 2010 Aug 15;90(10):1739-44. doi: 10.1002/jsfa.4010. PMID: 20564437.
从牛樟芝菌丝体中分离得到的4-acety lantroquinonol B抑制肝癌细胞的增殖
14. Ng LT, Lin CC, Hsu YL, Kuo YH, Lai M. Antiproliferative effect of different cultivated Antrodia cinnamomea on Hep G2, Hep 3B and PLC/PRF/5 hepatoma cells. Tajen Journal. 2007 Sep;31:69-78.
不同培养的牛樟芝对Hep G2，Hep 3B和PLC/PRF/5肝癌细胞的抗增殖作用
15. Pan JH, Chen YS, Sheen LY, Chiang BH. Large‐scale submerged fermentation of Antrodia cinnamomea for anti‐hepatoma activity. J. Sci. Food Agric. 2008;88:2223-2230. doi:10.1002/jsfa.3332
牛樟芝的大规模深层发酵抗肝癌活性
16. Wu WD, Chen PS, Omar HA, Arafa EA, Pan HW, Jeng J, Hung JH. Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma. Sci Rep. 2018 Aug 27;8(1):12914. doi: 10.1038/s41598-018-31209-8. PMID: 30150684; PMCID: PMC6110745.
牛樟芝可增强索拉非尼在肝细胞癌异种移植模型中的抗肿瘤活性
17. Zhu PL, Fu XQ, Li JK, Tse AK, Guo H, Yin CL, Chou JY, Wang YP, Liu YX, Chen YJ, Hossen MJ, Zhang Y, Pan SY, Zhao ZJ, Yu ZL. Antrodia camphorata Mycelia Exert Anti-liver Cancer Effects and Inhibit STAT3 Signaling in vitro and in vivo. Front Pharmacol. 2018 Dec 17;9:1449. doi: 10.3389/fphar.2018.01449. PMID: 30618745; PMCID: PMC6304454.
牛樟芝菌丝体在体外和体内均具有抗肝癌作用并抑制STAT3信号转导
十、Lung Cancer肺癌
1. Chan YY, Chang CS, Chien LH, Wu TF. Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell. J Ethnopharmacol. 2010 Feb 17;127(3):652-61. doi: 10.1016/j.jep.2009.12.008. Epub 2009 Dec 6. PMID: 19995598.
下调非小细胞肺癌A549细胞中四个肿瘤相关基因的表达来介导樟芝菌丝体的高效液相色谱作用
2. Chen PC, Chen CC, Ker YB, Chang CH, Chyau CC, Hu ML. Anti-Metastatic Effects of Antrodan with and without Cisplatin on Lewis Lung Carcinomas in a Mouse Xenograft Model. Int J Mol Sci. 2018 May 24;19(6):1565. doi: 10.3390/ijms19061565. PMID: 29794990; PMCID: PMC6032389.
具有和不具有顺铂的Antrodan对小鼠异种移植模型中Lewis肺癌的抗转移作用
3. Chen YY, Chou PY, Chien YC, Wu CH, Wu TS, Sheu MJ. Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways. Phytomedicine. 2012 Jun 15;19(8-9):768-78. doi: 10.1016/j.phymed.2012.02.016. Epub 2012 Mar 29. Erratum in: Phytomedicine. 2012 Dec 15;20(1):1-2. PMID: 22464013.
牛樟芝子实体的乙醇提取物通过MAPK和PI3K/AKT信号通路在腺癌CL1-0细胞中表现出抗迁移作用
4. Chiou JF, Wu AT, Wang WT, Kuo TH, Gelovani JG, Lin IH, Wu CH, Chiu WT, Deng WP. A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging. Evid Based Complement Alternat Med. 2011;2011:914561. doi: 10.1093/ecam/nep228. Epub 2011 Mar 13. PMID: 21785640; PMCID: PMC3137791.
非侵袭性分子成像对牛樟芝提取物治疗非小细胞肺癌的临床前评价
5. Kumar VB, Yuan TC, Liou JW, Yang CJ, Sung PJ, Weng CF. Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles. Mutat Res. 2011 Feb 10;707(1-2):42-52. doi: 10.1016/j.mrfmmm.2010.12.009. Epub 2010 Dec 24. PMID: 21185843.
Antroquinonol通过改变PI3K/mTOR蛋白和miRNA表达谱来抑制NSCLC增殖
6. Lu MK, Lin TY, Chao CH, Hu CH, Hsu HY. Molecular mechanism of Antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor β receptor degradation. Int J Biol Macromol. 2017 Feb;95:1144-1152. doi: 10.1016/j.ijbiomac.2016.11.004. Epub 2016 Nov 4. PMID: 27818294.
牛樟芝硫酸多糖通过诱导转化生长因子β受体降解而抑制肺癌细胞生长和迁移的分子机制
7. Lu MK, Lin TY, Hu CH, Chao CH, Chang CC, Hsu HY. Characterization of a sulfated galactoglucan from Antrodia cinnamomea and its anticancer mechanism via TGFβ/FAK/Slug axis suppression. Carbohydr Polym. 2017 Jul 1;167:229-239. doi: 10.1016/j.carbpol.2017.02.104. Epub 2017 Mar 6. PMID: 28433158.
牛樟芝硫酸半乳糖葡聚糖通过抑制TGFβ/FAK/Slu的抗癌机制
8. Wu CH, Liu FC, Pan CH, Lai MT, Lan SJ, Wu CH, Sheu MJ. Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model. Int J Mol Sci. 2018 Mar 9;19(3):791. doi: 10.3390/ijms19030791. PMID: 29522490; PMCID: PMC5877652.
牛樟芝乙醇提取物对肺癌A549细胞和C57BL/6J同种异体移植肿瘤模型细胞生长，迁移和耐药性的抑制作用
9. Wu H, Pan CL, Yao YC, Chang SS, Li SL, Wu TF. Proteomic analysis of the effect of Antrodia camphorata extract on human lung cancer A549 cell. Proteomics. 2006 Feb;6(3):826-35. doi: 10.1002/pmic.200401341. PMID: 16411266.
牛樟芝提取物对肺癌A549细胞影响的蛋白质组学分析
十一、Melanoma黑色素瘤
1. Hseu YC, Tsou HT, Kumar KJ, Lin KY, Chang HW, Yang HL. The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wnt/β-Catenin Signaling Pathways. Evid Based Complement Alternat Med. 2012;2012:197309. doi: 10.1155/2012/197309. Epub 2012 Sep 25. PMID: 23049605; PMCID: PMC3463817.
黑色素瘤细胞中牛樟芝的抗肿瘤活性：Wnt/β-Catenin信号通路的调节
2. Song M, Park DK, Park HJ. Antrodia camphorata Grown on Germinated Brown Rice Suppresses Melanoma Cell Proliferation by Inducing Apoptosis and Cell Differentiation and Tumor Growth. Evid Based Complement Alternat Med. 2013;2013:321096. doi: 10.1155/2013/321096. Epub 2013 Feb 25. PMID: 23533475; PMCID: PMC3596902.
发芽糙米上生长的牛樟芝通过诱导细胞凋亡，细胞分化和肿瘤生长抑制黑素瘤细胞的增殖
十二、Nasopharyngeal Cancer鼻咽癌
1. Wu TR, Huang TT, Martel J, Liau JC, Chiu CY, Leu YL, Jian WT, Chang IT, Lu CC, Ojcius DM, Ko YF, Lai HC, Young JD. Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells. J Ethnopharmacol. 2017 Apr 6;201:117-122. doi: 10.1016/j.jep.2017.02.008. Epub 2017 Feb 4. PMID: 28167294.
牛樟芝中的Pinicolol B诱导鼻咽癌细胞凋亡
十三、Oral Cancer口腔癌
1. Huang CC, Cheng HH, Wang JL, Cheng JS, Chai KL, Fang YC, Kuo CC, Chu ST, Ho CM, Lin KL, Tsai JY, Jan CR. Effects of Antrodia camphorata extracts on the viability, apoptosis, [Ca2+]i, and MAPKs phosphorylation of OC2 human oral cancer cells. Chin J Physiol. 2009 Jun 30;52(3):128-35. doi: 10.4077/cjp.2009.amh013. PMID: 19777798.
牛樟芝提取物对OC2口腔癌细胞活力，凋亡，[Ca2+]i和MAPKs磷酸化的影响
2. Tsai WC, Rao YK, Lin SS, Chou MY, Shen YT, Wu CH, Geethangili M, Yang CC, Tzeng YM. Methyl antcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6145-8. doi: 10.1016/j.bmcl.2010.08.006. Epub 2010 Aug 6. PMID: 20817519.
Methyl antcinate A通过Bax介导的线粒体凋亡途径在口腔癌细胞中诱导肿瘤特异性生长抑制
十四、Ovarian Cancer卵巢癌
1. Liu FS, Yang PY, Hu DN, Huang YW, Chen MJ. Antrodia camphorata induces apoptosis and enhances the cytotoxic effect of paclitaxel in human ovarian cancer cells. Int J Gynecol Cancer. 2011 Oct;21(7):1172-9. doi: 10.1097/IGC.0b013e31821f742c. PMID: 21897275.
牛樟芝诱导凋亡并增强紫杉醇对卵巢癌细胞的细胞毒性作用
十五、Pancreatic Cancer胰腺癌
1. Chen YJ, Chou CJ, Chang TT. Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells. Toxicol In Vitro. 2009 Apr;23(3):418-24. doi: 10.1016/j.tiv.2009.01.011. Epub 2009 Jan 22. PMID: 19344682.
化合物MMH01具有抗人类白血病和胰腺癌细胞的毒性
2. Yu CC, Chiang PC, Lu PH, Kuo MT, Wen WC, Chen P, Guh JH. Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. J Nutr Biochem. 2012 Aug;23(8):900-7. doi: 10.1016/j.jnutbio.2011.04.015. Epub 2011 Aug 12. PMID: 21840189.
天然的泛醌衍生物Antroquinonol诱导人胰腺癌细胞凋亡、自噬和衰老之间的串扰
十六、Prostate Cancer前列腺癌
1. Chen KC, Peng CC, Peng RY, Su CH, Chiang HS, Yan JH, Hsieh-Li HM. Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells. Nutr Cancer. 2007;57(1):111-21. doi: 10.1080/01635580701268360. PMID: 17516868.
牛樟芝可不同程度地抑制雄激素应答LNCaP和独立PC-3前列腺癌细胞
2. Ho CM, Huang CC, Huang CJ, Cheng JS, Chen IS, Tsai JY, Jiann BP, Tseng PL, Kuo SJ, Jan CR. Effects of antrodia camphorata on viability, apoptosis, and [Ca2+]i in PC3 human prostate cancer cells. Chin J Physiol. 2008 Apr 30;51(2):78-84. Erratum in: Chin J Physiol. 2008 Jun 30;51(3):196. PMID: 18666710.
牛樟芝对PC3前列腺癌细胞活力，凋亡和[Ca2+]i的影响
十七、Multi-drug Resistant耐药研究
1. Teng YN, Wang YH, Wu TS, Hung HY, Hung CC. Zhankuic Acids A, B and C from Taiwanofungus Camphoratus Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells. Biomolecules. 2019 Nov 21;9(12):759. doi: 10.3390/biom9120759. PMID: 31766413; PMCID: PMC6995581.
牛樟芝的樟菇酸A，B和C通过调节P-糖蛋白增强药物对耐多药癌细胞的细胞毒性
十八、不分科No classification
1. Arslan, Jamshed. You Complete Me: Natural Killer Cells Need TGF-Beta Inhibition to Effectively Combat Cancers. 32 Jul. 2018, www.novusbio.com/antibody-news/you-complete-me-natural-killer-cells-need-tgf-beta-inhibition-to-effectively-combat-cancers.
自然杀伤细胞需要抑制TGF-β才能有效对抗癌症
2. Huang CH, Chang CC, Lin CM, Wang ST, Wu MT, Li EI, Chang HC, Lin CC. Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine. Cancer Immunol Immunother. 2010 Aug;59(8):1259-72. doi: 10.1007/s00262-010-0852-y. PMID: 20390417.
牛樟芝作为免疫调节佐剂对HER-2/neu DNA疫苗抗肿瘤功效的促进作用
3. Lu MK, Lin TY, Chang CC. Chemical identification of a sulfated glucan from Antrodia cinnamomea and its anti-cancer functions via inhibition of EGFR and mTOR activity. Carbohydr Polym. 2018 Dec 15;202:536-544. doi: 10.1016/j.carbpol.2018.09.009. Epub 2018 Sep 6. PMID: 30287033.
牛樟芝中硫酸葡聚糖的化学鉴定及其通过抑制EGFR和mTOR活性的抗癌作用
4. Rashmi A Joshi. Antrodia camphorata with potential anti-cancerous activities: A review. J Med Plants Stud. 2017;5(1D):284-91.
牛樟芝具有潜在的抗癌活性：综述
5. Rao YK, Fang SH, Tzeng YM. Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts. J Ethnopharmacol. 2007 Oct 8;114(1):78-85. doi: 10.1016/j.jep.2007.07.028. Epub 2007 Aug 2. PMID: 17822865.
牛樟芝，冬虫夏草和肉桂皮提取物的抗炎和抗增殖肿瘤细胞活性评估
6. Stewart SG, Ho LA, Polomska ME, Percival AT, Yeoh GC. Rapid evaluation of Antrodia camphorata natural products and derivatives in tumourigenic liver progenitor cells with a novel cell proliferation assay. ChemMedChem. 2009 Oct;4(10):1657-67. doi: 10.1002/cmdc.200900238. PMID: 19731279.
用新型细胞增殖测定法快速评估致瘤性肝祖细胞中牛樟芝天然产物和衍生物
7. Yang CM, Zhou YJ, Wang RJ, Hu ML. Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights. J Ethnopharmacol. 2009 Jun 25;123(3):407-12. doi: 10.1016/j.jep.2009.03.034. Epub 2009 Mar 31. PMID: 19501273.
不同分子量牛樟芝多糖的抗血管生成作用及其机制
8. Yu YL, Chen IH, Shen KY, Huang RY, Wang WR, Chou CJ, Chang TT, Chu CL. A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation. Eur J Immunol. 2009 Sep;39(9):2482-91. doi: 10.1002/eji.200839039. PMID: 19701888.
从牛樟芝中分离出的methyl antcinate K促进树突状细胞活化和Th2分化
9. 张懿欣。樟芝栽培与其抗癌活性之研究。中医药年报，29-5，1-32。CCMP95-RD-044。
10. 邓文炳。樟芝防治癌症之重要机转与特色–癌症逆转。中医药年报，27-1，183-206。CCMP95-RD-007。
